The Keith House, located at 1900 S. Prairie Avenue, was designed by J. R. Roberts and completed in 1870. Among the four mansions considered part of the Prairie Avenue group (the Keith, Glessner, Kimball, and Coleman Houses), the Keith House is the simplest in design. Nearly all the details on the exterior of the house are derived from Classical and French motifs.

The house was owned by Eldridge G. Keith who came to Chicago in 1857 and went into the wholesale millinery business with his brothers, O.R. and Edison Keith. Their company, the Keith Brothers, was very successful. In 1884, Eldridge Keith became president of the Metropolitan National Bank, which later became known as the First National Bank of Chicago. Eldridge Keith was a business and civic leader.

In 1870, Keith moved to 1900 S. Prairie Ave. with his wife Harriet Hall of Ottawa, IL. He was followed by his brother Edison who built a house next door at 1906 S. Prairie Ave. It is rumored that an underground passage existed between the two properties beneath the driveways.

Eldridge Keith died in 1905, and the family kept the house until the 1920's. In 1934, the publishers, Domestic Engineering Company, bought the house and in 1966 Cahners Publishing Company Inc. acquired it. In 1975 architect Wibert Hasbrook bought the mansion and in 1978 the Keith House was purchased by Clarence Darrow's grandniece, Joy Darrow, and her husband Steven Pratt who established the Prairie Avenue Gallery in 1986. The house is now owned by Darrows' children and Woman Made Gallery has inhabited the first floor since 1997.